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01-Aug-2017 16:55

However, a drug screen and clearance calculation using five drug half-lives (T1/2) are not sufficient to exclude intoxication in all cases.

Drug screens are not sufficiently comprehensive to detect all drugs that may cause mental status depression.

Brain death is diagnosed clinically when an irreversible and proximate cause of brain injury is identified and no brain function is present upon clinical assessment [1, 2].

A prerequisite of the practice parameters for clinical testing is the absence of "drug intoxication or poisoning." The only evidence available regarding brain death determination in the setting of intoxication derives from case reports.

Drug screening in the clinical setting is not comprehensive, so a negative drug screen does not exclude intoxication.We recommend identification of drugs or toxins by careful history and targeted testing.An observation period of longer than five half-lives is appropriate when there is a possibility of an extremely large drug overdose, delayed drug absorption, delayed elimination, or interaction with another agent."Physical" is used to distinguish physical capital from human capital (a result of investment in the human agent)), circulating capital, and financial capital.[1][2] "Physical capital" is fixed capital, any kind of real physical asset that is not used up in the production of a product.

Usually the value of land is not included in physical capital as it is not a reproducible product of human activity.Even when the specific drugs are quantitatively identified, the use of kinetic data to determine clinical effects is limited because drugs often have prolonged half-lives in overdose.

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